Skip to main content
. Author manuscript; available in PMC: 2010 May 3.
Published in final edited form as: Circulation. 2008 Feb 4;117(7):952–962. doi: 10.1161/CIRCULATIONAHA.107.744490

Figure 5.

Figure 5

Metformin increases the translocation of LKB1 from nucleus into cytosol in HUVEC. A, Immunocytochemical staining of translocation of LKB1 from nucleus to the cytosols caused by metformin in HUVEC. B and C, Metformin (Met) also increases the amount of LKB1 in the cytosol while it decreases LKB1 in the nuclei in HUVEC. The blot is a representative of 5 blots obtained from 5 independent experiments. Con indicates control. D and E, Metformin increases the serine 428 phosphorylation of LKB1 in both nucleus and cytosol. The blot is a representative of 3 blots obtained from 3 independent experiments.