Table 1.
XRCC1 and breast cancer from the New York Site of the Breast Cancer Family Registry
| XRCC1 polymorphism | Genotype | Cases N (%) | Non-cases N (%) | OR (95% CI)* | Cases N (%) | Non-cases N (%) | OR (95% CI)** |
|---|---|---|---|---|---|---|---|
| CC | 227 (84) | 282 (86) | Reference | 212 (83) | 263 (86) | Reference | |
| R194W | CT, TT | 44 (16) | 45 (14) | 1.26 (0.69-2.28) | 42 (17) | 42 (14) | 1.17 (0.61-2.25) |
| GG | 250 (92) | 303 (91) | Reference | 249 (92) | 300 (91) | Reference | |
| R280H | GA, AA, | 23 (8) | 29 (9) | 0.94 (0.43-2.03) | 22 (8) | 28 (9) | 0.87 (0.38-2.00) |
| GG | 126 (46) | 139 (43) | Reference | 126 (46) | 139 (43) | Reference | |
| R399Q | GA, AA | 145 (54) | 184 (57) | 0.65 (0.42-1.02) | 145 (54) | 184 (57) | 0.64 (0.41-1.00) |
| GG | 126 (47) | 139 (43) | Reference | 119 (47) | 132 (44) | Reference | |
| R399Q | GA | 115 (42) | 141 (44) | 0.68 (0.43-1.07) | 107 (42) | 131 (43) | 0.65 (0.39-1.10) |
| AA | 30 (11) | 43 (13) | 0.44 (0.20-0.96) | 28 (11) | 38 (13) | 0.44 (0.18-1.11) |
*
Adjusted for age
**
XRCC1 R194W is adjusted for menopause and age; XRCC1 R280H is adjusted for age at menarche, BMI, and age; no confounders were identified for XRCC1 R399Q dominant model, co-dominant model with XRCC1 R399Q is adjusted for menopause and age