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. 2010 Jan 12;18(4):828–834. doi: 10.1038/mt.2009.291

Figure 1.

Figure 1

Intracellular uptake of siRNA and c-myc expression inhibited by siRNA formulation in vitro. (a) The structure of DSPE-PEG-NGR. (b) Fluorescence photographs of HT-1080 and HT-29 cells after treatment with 5′-Cy3-labeled siRNA against an irrelevant target in LPD-PEG-NGR and LPD-PEG-ARA for 4 hours. Western blot analysis of c-myc and β-actin in (c) HT-1080 cells and (d) HT-29 after treatment with 250 nmol/l siRNA in different formulations for 24 hours. (e) Immunocytochemical staining of c-myc after treatment with 250 nmol/l siRNA in different formulations for 24 hours.