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. Author manuscript; available in PMC: 2011 May 5.
Published in final edited form as: J Am Chem Soc. 2010 May 5;132(17):6183–6193. doi: 10.1021/ja100710j

Figure 1.

Figure 1

Caging and decaging of DNA. A caged monomeric building block (here, thymidine phosphoramidite) is incorporated into a deoxyoligonucleotide through standard DNA synthesis, rendering the oligomer inactive. Upon a brief irradiation with UV light, the caging group is removed, restoring the natural thymidine residue and thus the biological function of the DNA (e.g. the ability to undergo duplex formation, or catalytic activity). The 6-nitropiperonyloxymethylene (NPOM) caging group is shown in blue.