Figure 1.
Sequence variability of HIV, SHIV and SIV envelope protein in the C46 region of the HR2 of gp41 Env. HIV sequences were derived from 176 HIV-1 clade B strains (A) and compared to the HXB2 envelope region (aa 117-163 of gp41). SHIV sequences were derived from 13 rhesus monkeys infected with SHIV (B) and compared to the SHIV89.6P gp41 region (aa 117-163). SIV sequences from 27 rhesus monkeys infected with SIVmac239 or SIVmac251 (C) were compared to gp41 of SIVmac239 (aa 112-157 of gp41). The bars represent the percent amino acid change at a specific position and are color coded for each amino acid.