. Author manuscript; available in PMC: 2010 Nov 24.

Published in final edited form as: Cell Cycle. 2009 Nov 24;8(21):3519–3528. doi: 10.4161/cc.8.21.9888

Table 1.

A sample of some of the most well characterized modulations of membrane potential or ion channel activity, and the effect on cell proliferation

V_mem or channel examined	Effect	Cell type	Ref.
V_mem hyperpolarized through physiology	arrest	vascular endothelial	31
V_mem depolarized through high K⁺ media	proliferation	mouse macrophage cell line (PU5-1.8)	32
ClC-3 Cl⁻ channel activity	proliferation	glioma cell lines D54-MG and U251-MG	86
ENaC Na⁺ channel expression	proliferation	mouse colonic epithelium	89
EAG K⁺ channel activity	proliferation	multiple human melanoma lines	83
EAG K⁺ channel activity	proliferation	multiple human carcinoma lines	81
EAG K⁺ channel expression	proliferation	xenopus oocyte	160
ERG K⁺ channel activity	proliferation	multiple human cancer lines	73
ERG K⁺ channel activity	proliferation	quail neural crest	33
KCNK9 K⁺ channel activity	proliferation	human colorectal cancer tissue	79
K_V1.3, K_V1.5 K⁺ channel activity	proliferation	rat oligodendrocyte progenitors	39
C²⁺ dependent K⁺ channel activity	proliferation	prostate cancer cell line LNCaP	120
Ca²⁺ sensitive K⁺ channels inhibition	proliferation	colon carcinoma cell line T84	35
K⁺ channel inhibition	arrest	human and mouse lymphocytes	18, 22
K⁺ channel inhibition	arrest	chick astrocytes	20
K⁺ channel inhibition	arrest	hamster fibroblasts	21
K⁺ channel inhibition	arrest	rat Schwann cells	19