Figure 2. Comparisons of methylation of genomic CpG sites in CD4+ lymphocytes and breast and lung tissue samples.
a, Frequency distribution of CpG site methylation in 041896-001 (blue) and -101 (red) using ELAND-extended. b–j, Pairwise comparisons of CpG site methylation using ELAND-extended in CD4+ lymphocytes from monozygotic twin siblings 041896-001 and -101 (b), 230178-001 and -101 (c) and 041907-001 and -101 (d); inter-individual differences between CD4+ lymphocytes from 041896-001 and 041907-001 (e) and 041896-001 and 230178-101 (f); neoplastic differences between breast tissue and breast cancer (g) and between normal lung tissue and lung cancer (h); and between-tissue differences between CD4+ lymphocytes and breast tissue (i) and lung tissue (j).