Correlation between collagen variables and age of study participants at the time of the skin biopsy. The 95% CI for nondiabetic control subjects is indicated with punctuated lines. ●, conventional treatment group; ○, intensive treatment group. Regression lines are indicated by dashed lines for both treatment groups, with longer dashes for the conventional group. Units are picomoles per milligram collagen for furosine, CML, and pentosidine; arbitrary units for fluorescence; and percent of total collagen for acid- and pepsin-soluble collagen.