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Schematic representations of the chemical reactions involved in the formation of composite collagen–hyaluronic acid (HA) matrices. Type A matrices are composed of collagen and HACHO (top), whereas type B gels are derived from collagen/HACHO/HAADH (bottom). HACHO, HA derivatives carrying aldehyde groups; HAADH, hydrazide groups via reaction with adipic acid dihydrazide.
