Table 3.
Genes predicted to be regulated by PTHrP in the embryonic mammary mesenchyme. 30 genes were predicted to be up-regulated and 5 were predicted to be down-regulated. Six genes are regulated by or involved in BMP signaling. 18 genes were previously reported to be involved in mammary physiology or breast cancer.
| Gene Symbol |
BMP Signaling |
Mammary/ Breast Cancer |
|---|---|---|
| Up-regulated by PTHrP | ||
| Myl9 | ||
| Sim2 | + | |
| CD99 | + | |
| Tac1 | + | |
| Pcbp4 | ||
| Nnat | + | |
| Hmga2 | + | |
| Abcf1 | ||
| Igfbp4 | + | + |
| Si | ||
| Palld | ||
| Mmp2 | + | + |
| Mrg1 | ||
| 6330403K07Rik | ||
| Serpine 2 | + | |
| Sgta | ||
| Tgfbi | + | |
| Sostdc1 | + | |
| Hoxd9 | + | |
| Rspo1 | ||
| Inhbb | + | + |
| Fxyd6 | ||
| Rbp1 | + | |
| Thy1 | + | |
| Numa1 | + | |
| Bcam | ||
| Timp2 | + | |
| Gna12 | ||
| Tagln | + | |
| Orai1 | ||
| Down-regulated by PTHrP | ||
| Ctgf | + | + |
| Egfl6 | ||
| Vcam1 | ||
| Ptch1 | + | |
| Mme | + | |