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. 2010 May 3;5(5):e10436. doi: 10.1371/journal.pone.0010436

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Cohen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Representative Ki67 expression within live CD4+foxp3+ cells isolated from day 10 B16-bearing C57BL/6 mice treated with DTA-1 or IgG on day 4. B. and C. TIL were isolated from day 10 B16-bearing foxp3 ^GFP mice (n = 5/group) treated with DTA-1 or IgG on day 4 and examined by FACS. B. Mean fluorescence intensity (MFI) of GFP on live intra-tumor CD4+GFP+ cells. C. Intra-tumor CD8:Treg ratio of DTA-1- and IgG treated mouse in (B) is plotted against its foxp3^GFP MFI, demonstrating a significant inverse correlation between Teff:Treg ratio and foxp3GFP MFI in DTA-1 treated mice only (p = 0.03). Data are representative of 3 independent experiments.