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. 2010 May 3;5(5):e10438. doi: 10.1371/journal.pone.0010438

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Danilov et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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ACE activity in heparinized plasma (1/5 dilution in PBS) of members of the affected family, the father (F), mother (M), and brother (B) as well as in 5 healthy individuals (marked by initials) that served as controls was determined by fluorimetric assay of 40 µl diluted plasma with 200 µl each of substrates Hip-His-Leu (HHL) and Z-Phe-His-Leu(ZPHL) during 1 hour of incubation. A. ACE activity with HHL: mean (± SD) of three independent determinations. B. Ratio of hydrolysis of the two substrates (ZPHL/HHL ratio) in the tested samples, which is used to characterize for each catalytic domain of ACE in somatic two-domain ACE [28]. ND-not determined. * p<0.05 vs. control samples.