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. 2009 Jan 15;136(2):337–345. doi: 10.1242/dev.024463

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Fig. 4. — Increased expression and activation of Egf receptor in UB-derived cells of Met^fl/fl;HoxB7-Cre mice. (A) Immunostaining of E17 explant cryosections from Met^+/+;HoxB7-Cre and Met^fl/fl;HoxB7-Cre mice with α-Egfr and DBA. Cells from the DBA-positive UB tips (arrow) as well as the adjacent renal vesicle (arrowhead, RV) and metanephric mesenchyme show increased Egfr fluorescence. (B-E) Western blot analyses of renal papilla obtained from 6-week-old Met^+/+;HoxB7-Cre and Met^fl/fl;HoxB7-Cre mice. (B) Immunoblotted with α-Egfr and α-aquaporin-2, (C) α-pEgfr (Y1068) and α-E-cadherin, (D) α-pEgfr (Y992) and α-E-cadherin, (E) α-pErk5 and α-E-cadherin.