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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Int J Biochem Cell Biol. 2010 Jan 13;42(6):792–795. doi: 10.1016/j.biocel.2010.01.008

Figure 2.

Figure 2

Overview of Nlrp3 signalling pathways. Assembly and activation of caspase-1 within the cytosolic Nlrp3 inflammasome complex is induced by several stimuli including binding of ATP to the purinergic receptor P2X7, the ionophores nigericin and maitotoxin, β-amyloid and crystalline substances. Nlrp3 has been proposed to sense potassium efflux, the generation of ROS by the NADPH oxidase complex and lysosomal membrane disruption in response to these stimuli. Once activated in the Nlrp3 inflammasome, caspase-1 cleaves its substrates IL-1β, IL-18 and caspase-7 into the biologically active forms.