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Structures of resveratrol and SRT1720. Resveratrol is a natural product found in grapes and medicinal plants that activates SIRT1 (Howitz et al., 2003) and influences a number of other mammalian enzymes. SRT1720 is a novel SIRT1 activator described by Sirtris Pharmaceuticals (Milne et al., 2007), which is not thought to share off-target effects with resveratrol, with the possible exception of the norepinephrine transporter (Pacholec et al., 2010).
