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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Matrix Biol. 2010 Jan 22;29(4):304–316. doi: 10.1016/j.matbio.2010.01.005

Figure 3. Chondrogenic-like nodules develop in the valvular sinus of Adamts9+/LacZ heterozygous hearts.

Figure 3

Frontal sections stained with Movat pentachrome of Adamts9+/LacZ heterozygous hearts ages 9 (A,D), 15 (B,E) and 24 (C,F) weeks are shown. The areas within the green boxes in A, B, C are shown at higher magnification in D, E, and F respectively. The cells surrounded by blue matrix, indicative of sulfated proteoglycans, are in large lacunae, surrounding the lacunae is collagen (yellow). Boxes in G,H shown magnified in the respective inset. Arrowheads (A, B) denote fractured aortic arterial wall observed in all Adamts9+/LacZ heterozygous hearts examined (n=15). Ao-aorta; SLV- semi-lunar valve; At-atrium. Magnification bars: A = 475μm applies to B; C = 200μm; D = 30μm and applies to E and F.