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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Trends Endocrinol Metab. 2010 Jan 14;21(5):294–301. doi: 10.1016/j.tem.2009.12.004

Figure 3.

Figure 3

Biphasic effect of PGE2 on osteoclast formation in bone marrow macrophage (BMM) cultures. BMMs stimulated to become osteoclasts by treatment with RANKL and M-CSF. The addition of PGE2 to RANKL and M-CSF delays the appearance of osteoclasts. If there is only one measurement time, the conclusion as to the effect of PGE2 on RANKL-stimulation of osteoclast differentiation will depend on the day of measurement. On day 5, PGE2 “inhibits” and on day 7, it “stimulates.”