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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Trends Cell Biol. 2010 Mar 18;20(5):277–286. doi: 10.1016/j.tcb.2010.02.003

Table 2.

Ca2+ transport out of acidic stores

Calcium permeable channel General characteristics Associated human genetic diseases Acidic store
TRP channels (TRPML1, TRPML2, TRPML3, TRPM2, TRPV2) 6 TMD Mucolipidosis IV (TRPML1) Yeast vacuole [15]
Endosomes [46, 97]
Lysosomes [42, 97]
Two-pore channels 12 TMD ND Plant vacuole [17]
Endosomes [47, 48]
Lysosomes [47–49]
Inositol trisphosphate/Ryanodine receptors 6 TMD Congenital myopathies, Malignant hyperthermia (RYR1) Arrhytmias (RYR2) Paramecium contractile vacuole [99]
Plant vacuole [100]
Lysosome-related organelles [93, 101]
Golgi complex [39]
Secretory granules [34]

ND, not determined; TMD, transmembrane domains; TRPML, TRP mucolipins; TRPM, TRP melastatins; TRPV, TRP vallinoid