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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Adv Enzyme Regul. 2009 Nov 4;50(1):160–167. doi: 10.1016/j.advenzreg.2009.10.026

Figure 3. Runx1 responsive miR 24 regulates myeloid cell proliferation and differentiation by inhibiting an antagonist of the MAPK signaling pathway.

Figure 3

In normal myeloid progenitors (left side schematic), miR-24 is repressed by Runx1. This activates MAP kinase phosphatase 7 (MKP-7), which in turn blocks the activity of MAP kinase, thus down-regulating myeloid cell proliferation, concomitant with an increase in granulocytic differentiation. In AML patients, the leukemic AML1-ETO occupies the same site in the miR-24 promoter, but activates it. Activation of miR-24 down-regulates MKP-7 and up-regulates down-stream MAPK signaling. Activation of MAPK then leads to activated cell proliferation and inhibited myeloid cell differentiation, hallmarks of leukemia blast cells.