Table 6. Increase in CD44+/CD24-low Phenotype and Mammospheres in Drug Resistant Breast Cancer Cells1.
| % CD44+/ CD24-low |
Fold Increase in Drug Resistant Cells. |
Increased Presence of Mammospheres in Drug Resistant Cells. |
|
|---|---|---|---|
| MCF-7/DoxS | 2.2% | ||
| MCF-7/DoxR | 5.3% | 2.4 X | Yes |
| T47D/DoxS | 3.5% | ||
| T47D/DoxR | 10.2% | 2.9 X | Yes |
| MDA-MB-231 DoxS | 84% | ||
| MDA-MB-231 DoxR | 85% | 1X (no increase) | Yes |
1
The percentage of CD44+/CD24−/low cells was determined by FACS analysis in doxorubicin sensitive and resistant breast cancer cells.