Table 1.
Effects of acetaminophen treatment of mice on hepatic GSH levels.
| Time after Acetaminophen (h) | Wild Type | Cav-1−/− |
|---|---|---|
| Control | 7.2 ± 0.9 | 4.5 ± 0.8a |
| 1 | 0.6 ± 0.1b | 0.8 ± 0.1b |
| 3 | 0.7 ± 0.1b | 2.0 ± 0.9b |
| 6 | 4.6 ± 2.1 | 4.8 ± 1.0 |
| 18 | 4.7 ± 0.5 | 7.4 ± 1.5 |
| 24 | 5.8 ± 0.1 | 5.7 ± 1.7 |
Wild type and Cav-1−/− mice were treated with acetaminophen or control. Livers were collected 1–24 h later and analyzed for GSH content as described in the Materials and Methods. Data are presented as μmol GSH/g liver, mean ± SE (n = 3–5 mice).
a
Significantly different (P ≤ 0.05) from wild type mice.
b
Significantly different (p ≤ 0.05) from control.