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. 2010 Apr 1;18(7):2559–2565. doi: 10.1016/j.bmc.2010.02.043

Figure 2.

Figure 2

Exposure–response curves for poly(HPMA)–GFLG–AmB, poly(HPMA)–GFLG–AleA and poly(HPMA)–GLFG–AmB–AleA conjugates. (A) compares CIR1668 (9.6 wt % AmB) and CIR1791 (8.2 wt % AmB, 5.5 wt % AleA). (B) compares CIR1783 (16.9 wt % AmB), CIR1792 (13.4 wt % AmB, 3.9 wt % AleA) and CIR1793 (19.6 wt % AmB, 1.8 wt % AleA). CIR1790 contains 7.9 wt % AleA. AmB refers to the free drug tested (77% infected macrophages in control). Corresponding alendronic acid (AleA) equivalents at 1 μg/ml amphotericin B equivalent are as follows: 0.675 μg/ml for CIR1791, 0.290 μg/ml for CIR1792 and 0.092 μg/ml for CIR1793. CIR1790 was used at a starting concentration of 0.675 μg/ml, corresponding to the highest concentration in the combinatorial conjugates (92% infected macrophages in control). Data points give the arithmetic mean ± SEM (n = 4) for one representative experiment. Drug equivalent for combination polymers refers to amphotericin B.