Table 1.

Polymers prepared and evaluated

		Conjugate	Total AleA (% w/w)	Total AmB (% w/w)	Free AmB (% total drug)
1		Poly(HPMA)–GFLG–ONp		—	—
3	CIR1790	Poly(HPMA)–GFLG–AleA	7.9
4	CIR1791	Poly(HPMA)–GFLG–AmB–AleA	5.5	8.2	<1.0
5	CIR1792	Poly(HPMA)–GFLG–AmB–AleA	3.9	13.4	<1.0
6	CIR1793	Poly(HPMA)–GFLG–AmB–AleA	1.8	19.6	<1.0
7	CIR1668	Poly(HPMA)–GFLG–AmB	—	9.6	<0.1
8	CIR1783	Poly(HPMA)–GFLG–AmB	—	16.9	<0.1
9	CIR1465	Poly(HPMA)–GFLG–COOH	—	—	—
10	CIR1466	Poly(HPMA)–GFLG–AP	—	—	—

CIR1465, CIR1466 and CIR1668 have been reported previously.¹¹