Table 3.

Inhibition of hepatic parasite burden after treatment with CIR1668, CIR1783, CIR1791, CIR1792 and CIR1793

Code name	Conjugate	AmB loading	Ale acid loading	% Inhibition ± SEM	LDU ± SEM
CIR1668	Poly(HPMA)–GFLG–AmB	9.6 wt %	0	36.1 ± 10.4	1672 ± 139
CIR1783	Poly(HPMA)–GFLG–AmB	16.9 wt %	0	77.5 ± 3.0	1672 ± 139
CIR1791	Poly(HPMA)–GFLG–AmB–Ale acid	8.2 wt %	5.5 wt %	44.4 ± 2.6	1672 ± 139
CIR1792	Poly(HPMA)–GFLG–AmB–Ale acid	13.4 wt %	3.9 wt %	53.8 ± 5.2	1672 ± 139
CIR1793	Poly(HPMA)–GFLG–AmB–Ale acid	19.6 wt %	1.8 wt %	67.9 ± 6.9	1672 ± 139
AmBisome®	n/a	n/a	n/a	99.5 ± 0.2	1672 ± 139

Values presented give the arithmetic mean ± SEM of treated groups (n = 5).

LDU Leishman–Donovan unit at the experimental endpoint.