Table 1.

Drug inhibitors used for this study

Inhibitor name and abbreviation	Description
K252a	An ATP analog that has been described as a serine/threonine kinase inhibitor and as a selective and potent inhibitor different members of the tyrosine kinase family (Morotti et al., 2002; Tapley et al., 1992).
Tyrphostin (AG17)	Tyrosine kinase inhibitor that decreases the levels of p21 in OCI-Ly8 immunoblastic lymphoma cell line. Induces apoptosis (Palumbo et al., 1997).
Wortmannin (WORT)	PI3-Kinase inhibitor (Chen and Wang, 2001).
Cytochalasin D (CTC-D)	An actin-disrupting drug that affects macropinocytosis (Mercer and Helenius, 2008; Stevenson and Begg, 1994).
Brefeldin A (BFA)	Fungal macrocyclic lactone that affects the activation of the small GTPase Arf1 (Damm et al., 2005).
5-(N-Ethyl-N-isopropyl)-amiloride (EIPA)	Blocks Na+/H+ exchanger and a known inhibitor of macropinocytosis (Fretz et al., 2006; Nakase et al., 2004).
Staurosporin (STAU)	A protein kinase C (PKC) inhibitor and an inducer of apoptosis (Constantineseua et al., 1991; Wasilenko et al., 2001).
Genistein	Tyrosine kinase inhibitor (soy flavonoid) that blocks many different viruses at various stages (Andres et al., 2009).
Blebbistatin (BB)	A myosin II-depending inhibitor that inhibits VACV entry (Mercer and Helenius, 2008).