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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: J Am Chem Soc. 2008 Dec 24;130(51):17568–17574. doi: 10.1021/ja807066f

Figure 1.

Figure 1

Kinase – substrate cross-linking strategy. (A) Phosphorylation of the protein substrate by an upstream kinase. (B) The serine of the kinase is replaced with a reactive cysteine moiety that facilitates kinase – substrate cross-link by crosslinker 1.