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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: J Am Chem Soc. 2008 Dec 24;130(51):17568–17574. doi: 10.1021/ja807066f

Figure 3.

Figure 3

(A) Schematic representation of cross-linker 1 interacting with the hinge region of PKA. (B) Schematic representation of the aminopyrazole scaffold based cross-linker interacting with the hinge region of PKA. (C) Chemical structures of promiscuous kinase inhibitors 3 and 4. (D) Crystal structure of kinase inhibitor 4 bound to c-Src at 2.35 Å resolution. Key interactions and hydrogen bond distances are highlighted.