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. Author manuscript; available in PMC: 2011 Mar 5.
Published in final edited form as: Circ Res. 2010 Jan 7;106(4):712–719. doi: 10.1161/CIRCRESAHA.109.213702

Figure 3. Transcript levels of bone-related genes are increased in 12 month old Sox9fl/+;Col2a1-cre mice.

Figure 3

(A) Normalized fold changes in transcripts levels of osteogenic-signaling genes Runx2, Osteonectin (ON), Osteopontin (OP), Osteoprotegrin (OPG) and Smpd3 in Sox9fl/+;Col2a1-cre versus Sox9fl/+ control mice at 3, 6, and 12 months as determined by TaqMan Low Density Array (TLDA). *p<0.05. Osteonectin, undetected by in situ hybridization in control mitral valve leaflets (B), is detected in a 12 month Sox9fl/+;Col2a1-cre mouse mitral valve leaflet (arrows, C). Low magnification images (B, C) are available in Online Figure II.