Table 1.
Summary of fold-increases in the expression of surface markers and in cytokine production by human and mouse CD11c+ DC stimulated with L. lactis GEM, E. coli LPS (mDC) or TNF-α (hDC) as compared with mock-treated DC.
| Mouse CD11c+DC |
Human CD11c+DC |
|||||||
|---|---|---|---|---|---|---|---|---|
| GEM |
LPS |
GEM |
TNF-α |
|||||
| Neonatal | Adult | Neonatal | Adult | Neonatal | Adult | Neonatal | Adult | |
| Surface markers | ||||||||
| CD40a or CD83b | 1.0 | 1.3 | 1.0 | 1.3 | 2.2 | 3.6 | 2.9 | 3.0 |
| CD80 | 1.2 | 1.1 | 1.4 | 1.8 | 2.2 | 2.5 | 2.7 | 1.8 |
| CD86 | 4.0 | 7.2 | 4.2 | 6.1 | 5.1. | 6.9 | 4.8 | 5.1 |
| I-Ada or HLA-DRb | 1.1 | 8.9 | 0.9 | 7.2 | 1.4 | 3.1 | 1.4 | 3.2 |
| Cytokines | ||||||||
| IL-12p70 | 1.7 | 1.7 | 2.1 | 1.6 | 2.3 | 1.6 | 1.5 | 2.0 |
| TNF-α | 140.1 | 9.4 | 93.4 | 10.8 | 163.0 | 541.8 | 24.4 | 1,119.7 |
| IL-10 | 3.6 | 11.4 | 3.6 | 20.3 | 4.1 | 47.6 | 16.3 | 2.1 |
| IL-6 | 565.5 | 421.3 | 707.9 | 428.6 | 164.7 | 329.1 | 1,108.3 | 1.6 |
| IFN-γa or IL-1βb | 1.5 | 3.7 | 1.9 | 7.3 | 1.7 | 3.1 | 2.3 | 2.0 |
| MCP-1a or IL-8b | 1.4 | 1.7 | 2.9 | 1.7 | 58.9 | 13.4 | 125.5 | 2.6 |
one fold increase represents a response that is twice as high as the response of mock-treated cells.
a
Mouse only
b
Human only