Table 2.
TAQAS panel—sample | Sample type | Country of origin | HIV-1 Subtype | Estimated HIV RNA load (log10 copies/ml) | ARV drugs to which source has been exposed | No. NMs/insertions per TAQAS | No. DRMS per TAQAS |
|||
---|---|---|---|---|---|---|---|---|---|---|
Total | Complete | Partial | DRMs as NMs (%) | |||||||
1-A | P | Australia | B | 3.1 | d4T, RTV, AZT, 3TC, NFV, SQV, KAL | |||||
1-B | P | Australia | B | 5.1 | 3TC, ddI, d4T, T20, SQV, TDF, KAL, RTV, AZT, IDV, NFV, ABV, EFV, AZT | |||||
1-C | P | Australia | B | 4.0 | EFV, d4T, ABV, RTV, CBV, SQV, TPV, TDF, KAL, 3TC, AZT | 73 | 46 | 35 | 11 | 31 |
1-D | P | Australia | B | 4.7 | LPV, ABV, NVP, RTV, IDV | |||||
1-E | P | Australia | B | 5.0 | None | |||||
2-A | P | Australia | B | 5.3 | 3TC, ddI, d4T, T20, SQV, TDF, KAL, RTV, AZT, IDV, NFV, ABV, EFV, AZT | |||||
2-B | P | Australia | B | 4.7 | None | |||||
2-C | P | Australia | B | >4.0 | LPV, TDF, 3TC | 48 | 59 | 48 | 11 | 23 |
2-D | P | Australia | B | >4.0 | KAL, 3TC, ABV | |||||
2-E | SN | Uganda | D | ND | Not known | |||||
3-A | P | Australia | B | 4.7 | NVP, ddI, ABV, TDF, NFV | |||||
3-B | P | Australia | B | 4.7 | SQV, LPV, ABV, T20 | |||||
3-C | P | Australia | B | 4.7 | RTV, SQV, IDV, AZT, 3TC, ddI, d4T, NFV, EFV | 109/1 | 42 | 23 | 19 | 45 |
3-D | P | Australia | B | 4.5 | ABV, IDV, CBV, T20, RTV, TPN, 3TC, TDF | |||||
3-E | SN | Zimbabwe | C | ND | Not known |
P, plasma; SN supernatant for virus co-culture; ND, not done; d4T, stavudine; RTV, ritonavir; AZT, zidovudine; 3TC, lamivudine; NFV, nelfivanir; SQV, saquinavir; KAL, kaletra; ddI, didanosine; T20, enfurviritide; TDF, tenofovir; IDV, indinavir; Abacavir; ABV; EFV, efavirenz; CBV, combivir; TPV, tipranavir; LPV, lopinavir; NVP, nevirapine; NMs, nucleotide mixtures; DRMs, drug resistance mutations.