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Histological appearance consistent with NAFLD in ACAT2+/+ mice. Liver sections stained with hematoxylin and eosin from two ACAT2+/+ mice and two ACAT2−/− mice fed high cholesterol diets are shown. ACAT2+/+ livers had many large lipid droplets within the hepatocytes, whereas ACAT2−/− livers had fewer and smaller lipid droplets (arrows). The black bar in the upper right corner indicates 30 μm. WT, wild type.
