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Proposed mechanism for CspLOX2 with 18:2(n-6) as substrate. The initiating step of catalysis is the abstraction of a bisallylic pro-S hydrogen from C11 of 18:2(n-6) leading to the formation of a radical. Oxygen is then reversibly inserted at position C11 and can be converted to 11R-HPODE. Oxygen can alternatively be inserted at C9 or C13 to irreversibly form 9R-HPODE and13S-HPODE. As proposed by Ref. 10, free radical conversions are depicted.
