FIGURE 5.

Close-up of the binding pocket of InhA with bound NAD⁺ and PT70. Hydrogen bonds between PT70 (black) and Tyr¹⁵⁸ (yellow) as well as the NAD⁺ molecule (cyan) are indicated as red dotted lines. The important hydrophobic residues Ala¹⁹⁸, Met¹⁹⁹, Ile²⁰², and Val²⁰³ of the substrate-binding loop are shown in all bonds representation (red). An overlay of different triclosan inhibitors (PT70, black; triclosan, gray; 8PP, blue; JPL, green) in the binding pocket of InhA displays the differences in the orientation of the B-ring.