FIGURE 6.
AMPK regulates DUSP1 mRNA expression via p53 activation in response to glucose deprivation. A, HCT116p53+/+ and HCT116p53−/− cells were transfected with pcDNA, pAMPK-WT, or pAMPK-DN expression vectors for 24 h, and then exposed to glucose-depleted medium for 24 h. Then, the mRNA level of DUSP1 was determined. B, under identical conditions as Fig. 5E (right panel), the mRNA level of DUSP1 was determined. The data represent means ± S.E. for six determinations. (*, p < 0.05; compared with the indicated groups.)