AKAP79 inhibits AC2, -5, and -6. Membranes from HEK293 cells transfected with vector or AC2, -3, -5, -6, and -9 ± AKAP79 were stimulated with 50 nm Gαs (A) or 200 nm Gαs for AC9 (B). AC2, -5, and -6, but not AC3 or -9, were inhibited in the presence of AKAP79 (*, p < 0.05). Error bars in A and B indicate mean ± S.E.