FIGURE 6.

HMBPP/IL-2 cotreatment increases antimicrobial cytokine-producing Vγ2 and αβ T cells. Absolute numbers of CD3⁺ IFN-γ⁺ T cells that are Vγ2⁺, CD8⁺, or CD4⁺ upon ex vivo culture in media alone are shown per microliter of blood over time (a–c). Absolute numbers of CD3⁺CD8⁺TNF-α⁺ T cells after ex vivo restimulation with Gag peptide pool are shown per microliter of blood upon subtracting values obtained from stimulation with media only (d–f). Data are shown as averages ± SEM for groups treated with HMBPP plus IL-2, IL-2 only, or sham.