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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: Mol Ther. 2008 Aug 19;16(10):1695–1702. doi: 10.1038/mt.2008.168

Figure 4. Intracranial injection of AAV-CBA-hIFN-β causes regression of distal tumors in the brain.

Figure 4

Mice were infused with 5 × 1010 genome copies of either AAV-empty vector (AAV-ev) or AAV-CBA-hIFN-β by stereotaxic injection of the striatum (five mice per group). Two weeks post-injection, 5 × 105 U87fluc-mCherry glioma cells were implanted into the striatum of the contralateral hemisphere and mice were imaged for tumor-associated bioluminescent signal at the indicated time points post-tumor injection. AAV, adeno-associated virus; CBA, chicken β-actin; hIFN-β, human interferon-β. *P < 0.01.