Figure 7. Expression of human interferon-β (hIFN-β) from nontumor tissue causes regression of established tumors.

(a) 5 × 10⁵ U87fluc-mCherry cells were implanted into nude mice (four mice per group) and 2 weeks later, mice were infused with 4 × 10¹¹ genome copies of AAV-empty vector (AAV-ev) or AAV-NSE-hIFN-β. Mice were imaged as in Figure 1a. (b) Representative bioluminescent images of mice injected with AAV-ev (left image) or AAV-NSE-hIFN-β (right image), both at day 14 post-vector. Hematoxylin and eosin–stained coronal brain sections from either AAV-ev-treated animals (left image, day 38 post-tumor) or AAV-NSE-hIFN-B-treated animals (right image, day 49 post-tumor). Arrow points to glial scar.