Table 2.
Counts and Severity Ratings of Treatment Emergent Symptomsa During 1-Week Medication Lead-in Period (Days 1–8)
| Varenicline 2 mg/day (n = 10) | Placebo 0 mg/day (n = 10) | |
|---|---|---|
| Any Adverse Event | 3 | 4 |
| Nausea | 1 (minimal) | 0 |
| Sleep Difficulties | 1 (minimal) | 4 (minimal) |
| Abnormal Dreams | 1 (minimal) | 1 (minimal) |
| Constipation | 0 | 2 (minimal) |
| Flatulence | 0 | 1 (mild) |
| Vomiting | 0 | 1 (minimal) |
a
More than 5% and twice the rate seen in placebo-treated patients for smoking cessation; frequency counts do not differ by medication condition.