Skip to main content
. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: Pharm Res. 2007 Apr 25;24(9):1653–1659. doi: 10.1007/s11095-007-9295-3

Table II.

Pharmacokinetic Parameter Comparison of Fetal, Newborn, and Adult Sheep

Fetal (n = 6)
 Newborna (n = 4)
 Adultb (n = 5)
Cl (ml/h) V (ml/kg) Cl (ml/h) V (ml/kg) Cl (ml/h) V (ml/kg)
Baseline (Mean (C.V.)) 117 (37%) 116 (19%) 118 (11%) 74.4* (5%) 45.6* (24%) 52.3* (10%)
Post-phlebotomy (Mean (C.V.)) 159 (51%) 128 (16%) NA NA 90.2 (29%) 57.6* (8%)
a

From Veng-Pedersen et. al (20).

b

From Chapel et. al (18).

*

Significantly different from fetal sheep value (p < 0.05).

NA Not available.