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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: Lancet. 2009 Oct 12;374(9701):1627–1638. doi: 10.1016/S0140-6736(09)61376-3

Table 3.

Selected methods for autism diagnosis and categorisation

Description 0–3 years 3–5 years SA Adult Administration
time (min)
Checklist or inventory
Screening method
    Quantitative checklist for autism in toddlers29 Parent questionnaire, 25 questions X ·· ·· ·· 5–10
    Modified checklist for autism in toddlers30 Questionnaire 23 questions X ·· ·· ·· 10
    First year inventory31 Parent report 60 questions X ·· ·· ·· NS
    Early childhood inventory-432 Parent rating scale 108 items
Teacher rating scale, 87 items
·· X ·· ·· <20
    Child symptom inventory-433 Parent rating scale 97 items, teacher rating scale 77 items ·· ·· X ·· Variable
    Social communication questionnaire34 Parent interview or questionnaire 40 items ·· X X ·· 10–15
    Asperger’s syndrome diagnostic scale35 Parent or teacher rating scale 50 items ·· ·· X ·· 10–15
    Krug Asperger diagnostic index36 Parent, caregiver, or teacher questionnaire 32 items ·· ·· X ·· 10–15
    Autism spectrum quotient37 Parent questionnaire, for child, adolescent, and adult
50 questions
·· ·· X X NS
    Autism behaviour checklist38 Parent or teacher questionnaire 57 items ·· X X ·· 10–20
    Pervasive developmental disorder rating scale39 Rating scale 51 items X X ·· ·· NS
    Pervasive developmental disorder in mental retardation scale40 Clinician and teacher observation instrument 12 items ·· X X ·· 10–20
Dimensional assessment
    Developmental behaviour checklist,41 and developmental
    behaviour checklist—early screen42
Questionnaire; 96 items and 17 items X X ·· ·· 10–15
    Pervasive developmental disorder behaviour inventory43 Parent, caregiver, or teacher rating scale 8–10 subscales
(124–188 items)
X X X ·· 20–45
    Aberrant behaviour checklist44 Parent rating scale 58 items ·· X X ·· 20–30
    Child communication checklist45 Parent rating scale 70 items ·· X X ·· 5–15
    Social responsiveness scale46 Parent and caregiver questionnaire 65 items ·· X X X 15–20
    Repetitive behaviour scale—revised47 Parent and caregiver questionnaire 43 items X X X X 15–20
    Social and communication disorders checklist48 Parent and caregiver rating scale 12 items ·· ·· X X 10–15

Structured interview

Diagnostic method
    Parent interview for autism49 Parent interview 118 items X ·· ·· ·· 20–30
    Diagnosis of social and communication disorder schedule50 Semistructured caregiver interview schedule 2–4 h
administration, more than 300 items
·· X X ·· 180
    Autism diagnostic interview—revised51 Semistructured, investigator-based interview for caregivers X* X X X 90–180
Diagnostic method, dimensional assessment
    Developmental, dimensional, and diagnostic interview (3di)52 Caregiver computerised interview 183 items (demographics),
266 items (ASD related), 291 items (current mental state)
X X X X 45–90

Observational measures

Screening method
    Checklist for autism in toddlers53 Caregiver rating scale plus observations X ·· ·· ·· 10
    Screening tool for autism in children aged 2 years54 Clinician observation 12 items X ·· ·· ·· 20
Diagnostic method, dimensional assessment
    Autism observation schedule for infants55 Clinician observation 18 item X ·· ·· ·· 20
    Autism diagnostic observation schedule—modules 1–456 Standardised observation method X X X X 40–60
Diagnostic method
    Childhood autism rating scale57 History and observation 15 items (Likert scale) X X X X 20–30

SA=school-aged children. NS=not specified. ASD=austistic spectrum disorder. X=appropriate method

*

Mental age older than 2 years.

Training needed to administer this method.