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. Author manuscript; available in PMC: 2010 May 4.
Published in final edited form as: Trends Pharmacol Sci. 2008 Dec 11;30(2):79–84. doi: 10.1016/j.tips.2008.10.008

Figure 1.

Figure 1

Mechanisms for cannabinoid cross-desensitization of TRPV1 and TRPA1. Cannabinoids desensitize TRPV1 via activation of calcineurin and dephosphorylation of the ion channel. Homologous desensitization of TRPV1 can occur by application of TRPV1-selective cannabinoids (e.g. ACEA), and heterologous desensitization of TRPV1 can occur by administration of TRPA1-selective cannabinoids (e.g. WIN55212). Cannabinoids desensitize TRPA1 via activation of a calcium-independent pathway. Abbreviations: DAG, diacylglycerol; IP3, inositol (1,4,5)-trisphosphate; PHD, pleckstrin homology domain; PIP2, phosphatidylinositol (4,5)-bisphosphate; PLC, phospholipase C.