TABLE 3.
Comparisons of normalized signals from molecular parameters of interest to overall adenovirus viability as a function of disinfectant exposure and pH
| Molecular parameter (X/X0) | pH | CT (mg Cl2 per min/liter [avg ± SE])a | Adenovirus viability (N/N0 [avg ± SE])a | No. of data pointsb | Molecular parameter (X/X0 [avg ± SE])a | No. of data pointsb | P valuec |
|---|---|---|---|---|---|---|---|
| Hexon integrity (H/H0) | 7.4 | 0 | 1 | 4 | 1 | 4 | |
| 0.0090 ± 0.0043 | 0.43 ± 0.05 | 3 | 0.78 ± 0.06 | 3 | 0.019 | ||
| 0.0134 ± 0.0018 | 0.12 ± 0.01 | 5 | 0.74 ± 0.04 | 5 | <0.0001 | ||
| 0.0154 ± 0.0007 | 0.05 ± 0.01 | 5 | 0.63 ± 0.01 | 5 | <0.0001 | ||
| 10.0 | 0 | 1 | 1 | 1 | 1 | ||
| 1.08 | 0.44 | 1 | 0.73 | 1 | |||
| 1.35 | 0.054 | 1 | 0.87 | 1 | |||
| Fiber integrity (F/F0) | 7.4 | 0 | 1 | 4 | 1 | 3 | |
| 0.0090 ± 0.0043 | 0.43 ± 0.05 | 3 | 0.87 ± 0.04 | 3 | 0.003 | ||
| 0.0134 ± 0.0018 | 0.12 ± 0.01 | 5 | 0.88 ± 0.08 | 3 | <0.0001 | ||
| 0.0154 ± 0.0007 | 0.05 ± 0.01 | 5 | 0.98 ± 0.05 | 3 | <0.0001 | ||
| 10.0 | 0 | 1 | 1 | 1 | 1 | ||
| 1.08 | 0.44 | 1 | 0.68 | 1 | |||
| 1.35 | 0.054 | 1 | 0.63 | 1 | |||
| CAR affinity (C/C0) | 7.4 | 0 | 1 | 4 | 1 | 3 | |
| 0.0090 ± 0.0043 | 0.43 ± 0.05 | 3 | 0.66 ± 0.10 | 3 | 0.158 | ||
| 0.0134 ± 0.0018 | 0.12 ± 0.01 | 5 | 0.68 ± 0.06 | 3 | <0.0001 | ||
| 0.0154 ± 0.0007 | 0.05 ± 0.01 | 5 | 0.73 ± 0.14 | 3 | 0.002 | ||
| 10.0 | 0 | 1 | 2 | 1 | 3 | ||
| 0.94 ± 0.07 | 0.43 ± 0.05 | 3 | 0.77 ± 0.04 | 3 | 0.016 | ||
| 1.36 ± 0.01 | 0.07 ± 0.01 | 2 | 0.66 ± 0.08 | 2 | |||
| Attachment ability in | 7.4 | 0 | 1 | 3 | 1 | 3 | |
| cell culture (A/A0) | 0.0061 ± 0.0003 | 0.53 ± 0.07 | 3 | 0.64 ± 0.07 | 3 | 0.27 | |
| 0.0120 ± 0.0008 | 0.09 ± 0.03 | 3 | 0.46 ± 0.07 | 3 | 0.0007 | ||
| 10.0 | 0 | 1 | 3 | 1 | 3 | ||
| 0.85 ± 0.04 | 0.49 ± 0.04 | 3 | 0.70 ± 0.10 | 2 | 0.21 | ||
| 1.44 ± 0.09 | 0.12 ± 0.02 | 3 | 0.63 ± 0.05 | 3 | 0.00003 | ||
| DNA integrity (D/D0) | 7.4 | 0 | 1 | 3 | 1 | 3 | |
| 0.0061 ± 0.0003 | 0.53 ± 0.07 | 3 | 0.49 ± 0.02 | 3 | 0.44 | ||
| 0.0120 ± 0.0008 | 0.09 ± 0.03 | 3 | 0.43 ± 0.03 | 3 | 0.02 | ||
| 10.0 | 0 | 1 | 3 | 1 | 3 | ||
| 0.85 ± 0.04 | 0.49 ± 0.04 | 3 | 0.59 ± 0.04 | 3 | 0.26 | ||
| 1.44 ± 0.09 | 0.12 ± 0.02 | 3 | 0.62 ± 0.09 | 3 | 0.02 | ||
| Early protein synthesis | 7.4 | 0 | 1.00 ± 0.00 | 4 | 1 | 4 | |
| (E/E0) | 0.0074 ± 0.0003 | 0.46 ± 0.03 | 4 | 0.43 ± 0.02 | 3 | 0.47 | |
| 0.0130 ± 0.0006 | 0.08 ± 0.02 | 6 | 0.06 ± 0.02 | 7 | 0.59 | ||
| 10.0 | 0 | 1.00 ± 0.00 | 4 | 1 | 4 | ||
| 0.53 ± 0.05 | 0.81 ± 0.02 | 4 | 0.78 ± 0.10 | 4 | 0.86 | ||
| 0.87 ± 0.04 | 0.52 ± 0.03 | 3 | 0.42 ± 0.06 | 3 | 0.33 | ||
| 1.53 ± 0.08 | 0.10 ± 0.02 | 7 | 0.06 ± 0.02 | 7 | 0.23 |
a
Where no standard error is shown, the actual value is given.
b
Values are the number of unique data points analyzed for the given parameter.
c
P, values reflect statistical significance based on t test comparison of the given molecular parameter to adenovirus viability (N/N0).