TABLE 4.
MICs of different aminoglycoside antibiotics
| Antibiotic | MIC (μg/ml) for strain |
||||||
|---|---|---|---|---|---|---|---|
| SA113 | Δsdh (sdhCAB::spc)a | Δsdh (pRBsdh)a | Δlip (lip::spc)a | Δfdh (fdh::spc)a | hemB | menD | |
| Gentamicin | 1 | 2-4 | 2-4 | 1 | 1 | 32 | 32 |
| Tobramycin | 0.5-1 | 2 | 2 | 0.5-1 | 0.5-1 | 32 | 32 |
| Kanamycin | 2-4 | 8 | 8 | 2-4 | 2-4 | 64-128 | 64-128 |
a
These strains contain the same spectinomycin resistance cassette on the chromosome. The deletion mutants for the lipase gene (SA113Δlip) and formate dehydrogenase gene (SA113Δfdh) were constructed by G. Thumm and M. Leibig in our laboratory.