FIG. 6.

Pathogenic properties of A. baumannii strain 98-37-09 and ACJ2 cells in a murine-pneumonia model. (A) The averaged bacterial burdens of wild-type (98-37-09) and ACJ2 (A1S_2989 mutant) A. baumannii cells collected from the blood at 24 and 48 h after intranasal colonization (n ≥ 7); the horizontal line indicates the lower limit of detection. (B) The bacterial burdens of the wild type and ACJ2 obtained from lungs, hearts, and livers at 24 h (n ≥ 8) or 48 h (n ≥ 16) after intranasal colonization; the 48-h data points represent the results from two independent experiments; the horizontal lines indicate the lower limits of detection. The asterisks indicate statistically significant differences between the wild-type and ACJ2 bacterial burdens as determined by a two-tailed, unpaired Student t test (*, P < 0.05; **, P < 0.01). All data are shown as the log CFU ml blood or homogenized tissue⁻¹.