TABLE 2.
Protective immunity induced by Δpgk mutant immunization
| Mouse strain and inoculum | Mean (SD) log10 CFU in mouse spleen | Log10 U of protectiona |
|---|---|---|
| BALB/c | ||
| PBS | 7.07 (0.12) | |
| B. abortus RB51 | 6.49 (0.42) | 0.58* |
| B. abortus S19 | 6.13 (0.59) | 0.94* |
| B. abortus Δpgk strain | 6.11 (0.41) | 0.96* |
| C57BL/6 | ||
| PBS | 6.66 (0.14) | |
| B. abortus RB51 | 5.90 (0.41) | 0.76* |
| B. abortus S19 | 4.93 (0.15) | 1.73*# |
| B. abortus Δpgk strain | 5.30 (0.15) | 1.36*# |
| 129/Sv | ||
| PBS | 7.38 (0.20) | |
| B. abortus RB51 | 5.42 (0.19) | 1.97* |
| B. abortus S19 | 4.93 (0.42) | 2.46*# |
| B. abortus Δpgk strain | 4.10 (0.11) | 3.28*#† |
a
Significance is indicated as follows: *, P ≤ 0.05 compared to PBS control group; #, P ≤ 0.05 compared to the RB51-vaccinated group; †, P ≤ 0.05 compared to the S19-vaccinated group.