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Increased lung and spleen bacterial burdens in 5-LO KO mice following S. pneumoniae challenge. WT and 5-LO KO mice were infected with 106 CFU of S. pneumoniae cells via the intranasal (i.n.) route, and lung and spleen homogenates were assessed for bacterial burdens 24 and 48 h postinfection. Bars represent the means ± standard errors of the means for 8 to 10 mice per group from two separate experiments. *, P < 0.05 versus results for WT mice, using the Student t test. ND, not detected.
