FIG. 5.

CCR7⁺ T cells are sufficient for protective immune responses in CCR7^−/− mice. (a) T cells were isolated from spleens and lymph nodes of naive C57BL/6 or CCR7^−/− mice, and 5 × 10⁶ cells were adoptively transferred into CCR7^−/− mice (n = 5). C57BL/6 (n = 5) and nontransferred CCR7^−/− mice (n = 5) were sham injected with PBS. The survival curve is representative of four independent experiments with similar results. (b) Serum IFN-γ levels at day 7 postinfection. Averages and SEM are shown.