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The Sca2 mutant displays a small-plaque phenotype but replicates at wild-type levels within Vero cells. (A) Plaques of the R. rickettsii parent strain R and mutants 9-3 and 9-7. Scale bar = 5 mm. (B) Growth curves of the R. rickettsii parent strain R and mutants 9-3 and 9-7 in Vero cells. PFU were enumerated in triplicate. The error bars represent standard errors of the mean.
