. 2010 Mar 1;78(5):2240–2247. doi: 10.1128/IAI.00100-10

TABLE 2.

Presence or absence of Sca2 domains among various species of spotted fever group and typhus group rickettsiae^a

Group or species	SS	WH2-1	WH2-2	FH1	WH2-3	PRR	WH2-4	ATD
Spotted fever group^b	+	+	+	+	+	+	+	+
R. honeii^c	−	+	+	+	+	+	+	+
R. aeschlimanni^c	−	+	+	+	−	+	+	+
R. felis^c	+	+	−	+	−	−	+	+
R. canada^d	+	+	−	+	−	+	+	+
R. typhi^d	+	−	−	−	−	+	+	+
R. prowazekii^d	−	−	−	−	−	−	+	+

The presence of domains was determined by performing a BLASTp search using R. rickettsii Sca2 as the query, followed by amino acid sequence alignment in cobalt of the obtained matches. SS, Sec-dependent signal sequence; WH2, WH2 domain; PRR, proline-rich region; ATD, autotransporter domain. +, sequence retained; −, either the entire sequence is missing or the sequence maintained less than 50% identity to the consensus sequence.

Spotted fever group species that retained all identified domains: R. rickettsii strain Iowa (YP_001649468.1), R. rickettsii strain Sheila Smith (YP_001494228.1), R. conorii (NP_359747.1), R. siberica (ZP_00142412.1), R. japonica (AAT79540.1), R. parkeri (AAT79545.1), R. slovaca (AAT79549.1), R. massiliae (YP_001498970.1), R. peacockii (YP_002916397.1), R. montana (AAT79544.1), R. rhipacephali (AAT79546.1), R. australis (AAT79538.1), R. akari (YP_001492963.1), and R. africae (AAT79536.1).

Spotted fever group species that are missing 1 or more domains: R. honeii (AAT79535.1), R. aeschlimanni (AAT79542.1), and R. felis (YP_246083.1).

Typhus group Rickettsia species: R. canada (YP_001491816.1), R. typhi (YP_067021.1), and R. prowazekii (NP_220474.1).